Dr. Elliott Cheu, Professor of Physics, presentation given February 3, 2009, for the University of Arizona College of Science lecture series, "Science that Transforms." Since the time of the Greeks, humans have sought to understand the most fundamental constituents that make up all things. The 27 km circumference Large Hadron Collider (LHC), built in a tunnel beneath the French/Swiss border, is designed to smash protons into each other as they race at 99.999999% of the speed of light. The recent start-up of the LHC could allow mankind to journey further into the mystery of matter as we probe the processes of the first second of time following the Big Bang. Hear how UA physicists' involvement in this historic experiment is key to the LHC's potential.