October 11, 2006 lecture by David E. Shaw for the Stanford University Computer Systems Colloquium (EE 380). This talk describes the current state of the art in biomolecular simulation and explore the potential role of high-performance computing technologies in extending current capabilities. EE 380 | Computer Systems Colloquium: http://www.stanford.edu/class/ee380/ Stanford Computer Systems Laboratory: http://csl.stanford.edu/ Stanford Center for Professional Development: http://scpd.stanford.edu/ Stanford University Channel on YouTube: http://www.youtube.com/stanforduniversity/