The Hispanic Community Health Study / Study of Latinos (HCHS/SOL) is a multi-center epidemiologic study of 16,000 Hispanic/Latino participants in four U.S. cities: New York, Chicago, Miami, and San Diego. The study will determine the role that adopting cultural practices of the U.S. has on the prevalence and development of disease, and will identify risk factors playing a protective or harmful role in Hispanics/Latinos. The study is sponsored by the National Heart, Lung, and Blood Institute (NHLBI http://www.cscc.unc.edu/hchs/links ) and six other institutes, centers, and offices of the National Institutes of Health (NIH http://www.cscc.unc.edu/hchs/links ).